Nuclear proteins in genetically active and inactive parts of chromatin
نویسندگان
چکیده
منابع مشابه
Histones of Genetically Active and Inactive Chromatin
It has frequently been proposed that a variation in the relative content of lysine-rich, moderately lysine-rich, and arginine-rich histones might provide a mechanism by which specific portions of the genome may be genetically regulated. This possibility was investigated by comparing the electrophoretic pattern of these three fractions in cells differing markedly in their content of genetically ...
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TALE (transcription activator-like effector) proteins can be tailored to bind to any DNA sequence of choice and thus are of immense utility for genome editing and the specific delivery of transcription activators. However, to perform these functions, they need to occupy their sites in chromatin. In the present study, we have systematically assessed TALE binding to chromatin substrates and find ...
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Der Aufbau des Nukleosoms als Grundbaustein des Chromatins der Eukaryontenzelle, mit Ausnahme des Dinoflagellaten-Zellkerns, wird biochemisch und elektronenmikroskopisch vorgestellt als eine Einheit eines Oktamers aus Histonen (2 X H2A, 2XH2B, 2X H3, 2X H4) und einem Betrag von etwa 150 Basenpaaren DNA. Diese Partikel sind durch einen Zwischenbereich von weiteren etwa 50 Basenpaaren DNA verbund...
متن کاملCharacterisation of transcriptionally active and inactive chromatin domains in neurons.
The tandemly organised ribosomal DNA (rDNA) repeats are transcribed by a dedicated RNA polymerase in a specialised nuclear compartment, the nucleolus. There appears to be an intimate link between the maintenance of nucleolar structure and the presence of heterochromatic chromatin domains. This is particularly evident in many large neurons, where a single nucleolus is present, which is separated...
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* The work described in this paper was sponsored by the U.S. Atomic Energy Commission. t On leave of absence from the Department of Biochemistry, University College, London. 1 Rabin, B. R., and P. W. Trown, these PROCEEDINGS, 51, 497 (1964). 2 Ellman, G. L., Arch. Biochem. Biophys., 82, 70 (1959). 3Rabin, B. R., D. F. Shaw, N. G. Pon, J. M. Anderson, and M. Calvin, J. Am. Chem. Soc., 80, 2528 (...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1978
ISSN: 0014-5793
DOI: 10.1016/0014-5793(78)80530-4